This focus on height originally reflected a measure of successful GH replacement therapy GHRT after which treatment was ended. This was done, in part because hGH was originally extracted from human cadavers making its supply fairly limited.
However, with advances in technology it became possible to clone the gene capable of producing hGH. Thereafter, the recombinant form of human growth hormone rhGH became available in unlimited quantities.
Because of its availability for clinical application, rhGH became and is now the drug of choice, not only because of its efficacy, but also because it avoids the risk of transmitting fatal, slow viral prion-mediated Creuzfeldt Jacob Disease which was sometimes associated with the cadaver-derived hormone.
This action was taken because people who had been treated with rhGH as children and then routinely discontinued from treatment upon reaching final height, experienced higher than expected rates of medical problems as adults, beginning in their 30s and 40s. These included reduced physical, mental, and social energy, excess adipose tissue, diminished muscle mass, diminished libido, poor bone density, higher than normal cholesterol levels, and elevated rates of cardiovascular disease.
Research trials soon confirmed that a few months of GH replacement therapy could improve nearly all of these parameters in GHD patients. Coincidentally, it was noticed that the same intrinsic diseases as well as maladaptive changes in form and function also occur spontaneously with advancing age. The progressive age-associated decrements in function of the GH neuroendocrine axis are collectively referred to as the somatopause.
The term represents cessation of optimal secretion of somatotropin hGH which is analogous to declining production of reproductive hormones during the menopause and andropause in women and men, respectively.
Initial investigations into the causes of adult onset GHD showed them to result from damage to the pituitary gland due to tumors, surgery or radiotherapy that disrupted function of the GH neuroendocrine axis.
For these reasons, administration of rhGH which is the accepted treatment for GHD, has not been permitted for use in aging by regulatory guidelines promulgated by the FDA. If used at all, lower doses are recommended in the elderly to reduce the incidence of side effects and maintain age-dependent normal levels of IGF This is a confusing recommendation for the following reason. However, serum IGF-1 values in both groups are indistinguishable by the age of Instead the range of laboratory reference values are shifted downward to reflect those in human subjects as they advance in age.
Surprisingly, this is a unique practice which is not done for serum values of any other hormones. Nonetheless, it restricts in part, diagnosis of idiopathic GHD and treatment with rhGH to those under 40, and thereby requires different treatments for medical issues related to age-associated, GH insufficiency. To differentiate between classically defined adult-onset and age-related GHD associated with the somatopause, the latter is often called growth hormone insufficiency GHI.
Thus, because of the similarities between GHD resulting from trauma, disease or radiation from effects of aging that occur during middle and later stages of life, endocrine therapies for treating the latter condition have been sought over the past two decades. Aerobic capacity, muscle mass, and strength all progressively decline with age. Loss of muscle mass, or sarcopenia, and the accompanying reduction in strength increases the risk of falls and their complications, and for many individuals the associated loss of physical, functional capacity leads to increasing difficulty in living independently.
Complaints of poor sleep are common in older populations. Insomnia reduces quality of life and is often a factor in decisions to seek health care. Sleep complaints often lead to overmedication and sedation of the elderly, with the numerous potential attendant problems, including increased morbidity and mortality.
This effect is separate from the alterations in body mass index that accompany the normal aging process. This decline in GH production is initially clinically silent, but may contribute over time to sarcopenia and frailty.
In particular, such treatment could reduce the loss of muscle mass, strength, and exercise capacity that leads to frailty; thereby prolonging the ability to live independently. Growth hormone secretagogues GSHs are a class of molecules that stimulate the secretion of GH from the pituitary gland. They include agonists of the hypothalamic and pituitary ghrelin receptors GHRPs, ipamorelin, hexarelin, etc.
Sermorelin is a synthetic man-made version of naturally occurring GHRH that is produced in the brain and can be used clinically to stimulate release of growth hormone GH from the pituitary gland. Thus, Sermorelin can be effective in cases of GH insufficiency and thereby sustain essential bodily functions throughout life.
Sermorelin is the most widely used member of the GHRH analogue drug class. It can significantly promote the synthesis and release of growth hormone GH from cells in the pituitary gland, improving the serum concentrations of GH and subsequently insulin-like growth factor 1 IGF-1 in animals and humans. The positive and negative opposing regulation of growth hormone by GHRH and somatostatin, respectively, creates a rhythmic-circadian pattern of GH secretion.
Sermorelin acts on the growth hormone releasing hormone receptor GHRHr in the pituitary to regulate cellular activities. This receptor regulates growth hormone release directly by stimulation and indirectly by a feedback relationships with somatostatin. Sermorelin is readily degraded after reaching the bloodstream, having a biological half-life of approximately min. In addition to increasing production and secretion GHRH also affects sleep patterns by increasing the amount of slow wave sleep SWS while augmenting sleep-related GH secretion and reducing cortisol secretion.
To exert all its beneficial effects, Sermorelin requires a functioning pituitary and a host of peripheral tissues. More precisely, functioning growth hormone releasing hormone receptors GHRHr are required on somatotrophs in a functioning anterior pituitary. It also can be used to oppose maladaptive changes in body composition such as reduced lean body mass muscle , increased total and visceral fat, and decreased bone mass resulting from low or inadequate concentrations of serum GH and insulin-like growth factor-1 IGF Adults with inadequate concentrations of serum GH can have a variety of signs and symptoms, some of which include abnormal body composition, reduced fluid volume, diminished strength, physical energy and stamina, lack of motivation, lethargy, lability etc.
Symptoms of growth hormone deficiency also depend on age, and often those meeting the classic definition of adult onset GHD can have different symptoms than a child similarly diagnosed. However, those with adult-onset GHD that are causally unrelated to aging have similar clinical symptoms as those that occur progressively in incidence and severity with advancing age. Some people will only have one or two while others can have multiple symptoms.
Fortunately, certain tests and exams can help physicians to make an appropriate diagnosis. Diagnosing growth hormone deficiency typically starts with a physical exam. The physician checks weight, height, and body proportions. Other than a physical exam, there are many other tests and exams used to make a growth hormone deficiency diagnosis. Some or all of the following tests can be used to diagnose age related GH insufficiency, since everyone will be so affected over the course of their lives.
Such diagnostic testing may be used to determine the degree to which replacement therapy is indicated, i. Tests include:. In addition to blood tests, a physican may perform some additional exams and tests to help diagnose growth hormone deficiency. These may include:.
While aging is not a disease, it results in significantly maladaptive changes in body composition and function which affect the individual and the community at large. While aging is associated with a milder form of adult GHD, GH replacement with secretagogues such as Sermorelin has met with success. Once daily injections can stimulate increases in GH and IGF-I at least to the lower part of the young adult normal range. Since iv injections are impractical for most people, the sc route is commonly used to administer doses of Sermorelin ranging between 0.
The most commonly used dosage is 0. As with GH, subjects showed an increase in lean body mass and a decrease in body fat particularly abdominal visceral fat. Thus, since the aging pituitary remains responsive to GH and GHS, it is reasonable that stimulation with Sermorelin is indicated in aging.
CJC is a synthetically produced peptide that can increase your plasma growth hormone levels. CJC is usually injected into your body via a subcutaneous injection. Initially CJC was developed to treat diseases and medical conditions for patients who had muscle disorders, diseases, and burn victims.
CJC has drawn many individuals like athletes from around the globe for its incredible benefits and minimal side effects to enhance their performance on the field, and in the gym. Lean body mass, gains in muscle mass, and increased strength. These are just a few of the benefits which CJC will deliver upon. It is a long-acting GHRH analog or growth hormone releasing hormone. The lifespan for releasing growth hormones is promulgated by tetrahedral modifications of CJC, and the drug affinity complex DAC.
Therapeutic effects are increased because of this, and users require fewer injections in comparison to other growth hormones. These are just a few of the benefits CJC users will appreciate in comparison to other growth hormone injections available on the market. Of course many users will complain of side effects as it pertains to using supplements or injections.
This typically lasts for a period of 30 minutes to 2 hours, post-injection. Additionally, itching, pain, redness, and soreness are often noted as side effects at the injection point, although this is not reported with all users. Research suggests this can lead to: increased muscle strength, fat metabolism, and muscular mass. Improved skin-tone and muscle definition are also noted.
For those who want to further enhance CJC with DAC effects will find that proper diet and exercise regimens will help in doing just that. Those who participate in studies for HGH often are given injections 2 to 3 times daily. This is typically before breakfast, before bed, and post-workout. These test periods can last up to several weeks in order to determine the actual CJC benefits on test-subjects.
They are also meant to mimic as closely as possible, the actual secretion of the hormones. The half-life of DAC is an 8 day period, and for this reason the cycles are usually shorter in duration. So the injections are only given once weekly, which result in increased GH secretion levels. For those on the weekly cycle, one evening injection of GHRP 6 is administered; this is done at night because it causes less of a cortisol surge, and prolactin, in comparison to GHRP 2.
Once adolescent growth ceases, it is difficult for the body to produce HGH in such high volumes as it did, making it harder to build lean muscle mass. HGH has helped in development of children who were deficient in the growth hormone, and this sparked a synthetic version to be created in Several studies have since been conducted, detailing how HGH has helped build muscle mass, decrease body fat, and otherwise benefit adult users.
Research has shown that administering CJC once weekly helps to increase plasma GH concentrations times more for a period of up to 6 days after injection. Further, it increases IGF-1 levels by 1. The injection is non-pyrogenic, sterile, and intended for subcutaneous or intramuscular injection use. It is to be administered after reconcentration with sterile water for injection purposes.
An insulin syringe can be used for subcutaneous injection, with a 2 mg CJC dosage per injection. Per vial, a 1 X 2 ml injection is to be administered. When using. When using 1 ml of water, this equates to 2 mg dosage 1 ml or units. The intended frequency is once weekly, with 2 mg dosage, due to the prolonged half-life.
When using CJC it is important to follow proper dosage instructions. Depending on whether you are going to use the injection in the morning or evening hours, the frequency at which you will be injecting the syringe will differ. A nighttime injection should be given on an empty stomach best for use at night due issues with drowsiness. It should be taken hours after your last meal. There really is no guesswork as it pertains to using the CJC What more could users ask for?
The product is far superior. In addition to these reviews, it is noted that CJC has helped increase blood serum levels, of HGH, within 3 to 11 days after inception of use.
By adding DAC you also allow for the greater possibility of utilizing smaller Growth Hormone pules which was once thought of as a bleed, and when combined with a GHRP it can activate Growth Hormone stores the be released throughout the night at day. By stimulating cell growth, CJC will help improve skin-immunity, as well as internal organ-mass.
Users further report that their sleep patterns are improved. This is essential to help in muscle development, and overall health. The main purpose of CJC is to boost protein synthesis levels, and help fuel the growth of muscle tissues in the body. Many benefits will be derived by users who are incorporating CJC to their regimen; among these are:.
But if you are looking to not inject as much daily and still want to have a more powerful GH stores, then about 2- times a week you should choose to inject the CJC with DAC. Because it stimulates the pituitary gland, those who are using higher doses of CJC might notice water retention in their body. Simply skip a dose, or reduce intake levels of sodium if you notice this issue.
Water retention and increased levels of tiredness have also been reported by some users. After a couple of weeks, once the body has adapted, these issues typically resolve themselves. For those who notice these issues, it might be necessary to change your injection schedule, and only inject the CJC prior to bedtime, as opposed to in the morning hours.
Each vial contains 20 X mcg doses. Injection amount: If using 1 ml of water for mcg dosage — use. For 2 ml of water,. Frequency: mcg should be injected 1 to 3 times daily, best if injected with to mcg of GHRP peptides. For best results, subcutaneous injections are suggested. Wash your hands and gather all materials, also clean the vial with alcohol prior to injection. To prevent infection it is best to use an alcohol pad to wipe the skin prior to injection.
The best places to inject include the lower stomach, thigh, or upper arm. You should wait at least 30 minutes after your injection to consume any food or liquid.
What is Ipamorelin peptide? Ipamorelin significantly increases plasma growth hormone GH levels in both animals and humans. How long do peptides last in the fridge?
Storage of Reconstituted Peptides If stored at room temperature they may begin to degrade after as little as 24 hours. Therefore we recommend storing them in the fridge as soon as possible after mixing. Stored in the fridge they will remain potent for around 8 weeks before beginning to degrade.
What is tb? TB is the synthetic version of a powerful protein known as Thymosin Beta As such, TB has potent healing properties that facilitate a speedy recovery from injuries. That's why it's commonly used in the animal racing world to improve performance and reduce the occurrence of injuries. Can you buy bacteriostatic water?
HCGSupplies has no Bacteriostatic water shortage. Order as much as you need. How long is HGH good for once mixed? After reconstitution, store vials mixed with bacteriostatic water for injection under refrigeration at 2 to 8 degrees C 36 to 46 degrees F and use within 14 days. For vials mixed with sterile water for injection, the solution should be used immediately, and any unused portion should be discarded.
What is BAC water? If an optimal injection time had to be picked, it would be in the evening before bed. How to Take: By subcutaneous injection into fat stomach, thigh or buttock or intramuscularly bicep or shoulder with an insulin syringe.
Other peptides can be mixed in the same syringe and injected at the same time. Possible Benefits: Fat loss, muscle gain, increased strength, improved skin tone, better sleep, more energy, stronger bones and connective tissues. HCG iu. PT Bremelanotide.
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